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Nortriptyline shouldn't be given with adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, phenylpropanolamine, medication which are metabolized by CYP4502D6, MAOIs, guanethidine, debrisoquine, bethanidine, clonidine and reserpine and many others.

Barbiturates could improve the rate of metabolism of nortriptyline. Lactation: Gabapentin could also be secreted by way of the breast milk like many other drugs , so it should be used in girls who are nursing, provided that the advantages clearly outweigh the risks.
Nortriptyline crosses the placenta and is found in the breast milk. Nortriptyline and its metabolites are primarily excreted in the urine, the place solely small amounts (2%) of the total drug is recovered as unchanged dad or mum compound. Nortriptyline is used for the treatment of depression and nocturnal enuresis.
8000 mg/kg. Signs of overdose are in keeping with the drug's hostile effect profile and involve CNS depression (e.g. dizziness, drowsiness, slurred speech, lethargy, lack of consciousness) and gastrointestinal signs comparable to diarrhea.

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